Dr. McFarlane – Improving AMD Treatments By Studying Cell Movement
Scientific Title: Movement of Retinal Pigment Epithelium Cells during Development and in Injury
Lead Investigator: Dr. Sarah McFarlane
Institution: University of Calgary
Granted: $277,248 over 5 years, 2015–2020
Dr. Sarah McFarlane is studying how retinal pigment epithelial (RPE) cells move with the hope that it may help improve treatments for age related macular degeneration (AMD). AMD involves the damage to RPE cells which provide critical support functions for photoreceptors, the light sensing cells of the retina. Dr. McFarlane will use gene editing techniques to identify molecules that influence RPE cell movement. Cell replacement therapies are being studied as an innovative treatment for AMD. To be successful, healthy RPE cells will need to migrate from the site of injection to the sites of RPE cells damage. Dr. McFarlane hopes that work from this study will be used to increase the success of cell replacement therapy for AMD.
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