Dr. Borschel – Finding New Treatments for Blindness Caused by Neurotrophic Keratopathy
Scientific Title: Novel treatments for blindness caused by neurotrophic keratopathy: role of stem cells, innervation, and therapeutics
Lead Investigator: Dr. Gregory Borschel
Institution: The Hospital for Sick Children, Research Institute
Granted: $300,000 over 2 years
Neurotrophic keratitis is a degenerative disease that affects the clear outer layer of the eye, called the cornea. In patients with neurotrophic keratitis, nerves in the eye are damaged and the cornea loses the ability to sense stimulation. This leads to scarring, and eventually vision loss. In this project Dr. Borschel’s team will use an animal model of neurotrophic keratitis which they have developed to test strategies to improve nerve regeneration and to identify drugs that can increase the ability of the cornea to heal.
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